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Demographics, disease duration, baseline headache/migraine frequency, and treatment outcomes (oral, BTX-A, and CGRPmab) Classification as resistant(rM)or refractory(RM) according to EHF2020 criteria.Data was analysed using base r and the mgcv packages

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[17] However, no large-scale, controlled trials have evaluated the efficacy or safety of ALA for pregnant patients, and thus there is insufficient evidence to consider it definitively safe